Dysfunction of V-type ATPases has been implicated in various diseases, including neurodegenerative disorders, cancer, and osteoporosis. For instance, mutations affecting the subunits of V-type ATPases can lead to lysosomal storage disorders. In cancer, overexpression of V-type ATPases can contribute to the acidic tumor microenvironment, promoting cancer cell survival and metastasis. Understanding the catalytic mechanisms and regulation of V-type ATPases can provide insights into therapeutic strategies for these conditions.
