What is the catalytic mechanism of V-type ATPases?
The catalytic mechanism of V-type ATPases involves the binding and hydrolysis of ATP in the V1 domain, which induces the rotation of a rotor-like structure. This rotational movement is coupled with the translocation of protons through the Vo domain across the membrane. This process is driven by conformational changes and the release of energy from ATP hydrolysis, a mechanism often described as a rotary motor.
