phosphoglycerate kinase

What is the Importance of Phosphoglycerate Kinase in Metabolism?

PGK is vital in the glycolytic pathway because it is responsible for one of the two substrate-level phosphorylation steps that directly generate ATP. This step is particularly important in anaerobic conditions where oxidative phosphorylation cannot occur. By generating ATP at this stage, cells can continue to produce energy even in the absence of oxygen. Furthermore, the product of the PGK-catalyzed reaction, 3-phosphoglycerate, is a crucial intermediate for other metabolic pathways, including the Calvin cycle in photosynthesis and the serine biosynthesis pathway.

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