phosphoglycerate kinase

What Factors Influence the Activity of Phosphoglycerate Kinase?

Several factors can affect the activity of PGK, including pH, temperature, and the concentration of substrates and products. Optimal activity is usually observed at physiological pH and temperature. Additionally, the enzyme can be regulated by feedback mechanisms, where the accumulation of ATP or 3-phosphoglycerate inhibits its activity to prevent overproduction of ATP and maintain metabolic balance.

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