What are the Limitations of Sharpless Asymmetric Epoxidation?
1. Substrate Limitation: The reaction is primarily limited to allylic alcohols. Other substrates may not perform as well. 2. Environmental Concerns: The use of titanium and organic peroxides raises concerns regarding waste and safety. 3. Cost: The chiral tartrate ligands and titanium isopropoxide can be relatively expensive, which might be a limitation for large-scale industrial applications.
