Catalysis plays a pivotal role in Reppe vinylation. The reaction typically requires a catalyst to proceed efficiently and selectively. Catalysts lower the activation energy, increase reaction rates, and improve product yields. In Reppe vinylation, metal catalysts, especially those based on nickel or cobalt, are commonly used. These catalysts facilitate the formation of a metal-carbon bond, which is crucial for the addition of acetylene to the carbonyl compounds.