What Are the Challenges of Solvent-Free Reactions?
While solvent-free reactions offer numerous benefits, they also pose certain challenges:
Heat Management: Without solvents to absorb and dissipate heat, managing exothermic reactions can be more difficult. Mass Transfer: In the absence of a solvent medium, ensuring effective mass transfer between reactants can be challenging. Reaction Kinetics: The kinetics of solvent-free reactions can be different from those in solution, requiring careful optimization.
