Despite its advantages, cross coupling faces several challenges:
1. Catalyst Deactivation: Catalysts can become deactivated, reducing reaction efficiency. 2. High Cost of Catalysts: Transition metals like palladium are expensive. 3. Environmental Concerns: Some organometallic reagents and solvents used can be toxic and harmful to the environment. 4. Reactivity and Selectivity Issues: Achieving high reactivity and selectivity simultaneously can be difficult.
