Despite the benefits, SMSI poses several challenges: - Stability: The strong interactions can sometimes lead to irreversible changes in the catalyst, affecting long-term stability. - Complexity: The phenomenon is highly dependent on the specific metal-support combination and treatment conditions, making it challenging to generalize the findings. - Characterization: In-situ characterization techniques are required to fully understand the dynamic changes occurring during SMSI, which can be technically demanding and expensive.