How Does Catalysis Play a Role in Transcription Initiation?
Catalysis in the context of the transcription initiation complex primarily involves the facilitation of chemical reactions that are crucial for the formation of the complex and the initiation of transcription. The process includes the phosphorylation of RNA polymerase II by kinases within the TFIIH complex, which is a key regulatory step. This phosphorylation event is catalytic and induces conformational changes in the polymerase, enabling it to begin RNA synthesis.
