Which Enzymes are Involved in Lipoprotein Catalysis?
Several key enzymes are involved in the catalytic processes associated with lipoproteins:
- Lipoprotein Lipase (LPL): Catalyzes the hydrolysis of triglycerides in VLDL and chylomicrons into free fatty acids and glycerol, which can be taken up by tissues. - Hepatic Lipase (HL): Acts on intermediate-density lipoproteins (IDL) and HDL to modify their lipid content. - Lecithin-Cholesterol Acyltransferase (LCAT): Catalyzes the esterification of cholesterol within HDL particles, a crucial step in reverse cholesterol transport. - Cholesteryl Ester Transfer Protein (CETP): Facilitates the transfer of cholesteryl esters and triglycerides between lipoproteins, influencing their composition and function.
