What Types of Catalytic Reactions Are Associated with GPCRs?
GPCRs are involved in a variety of catalytic reactions, primarily those associated with signal transduction pathways. These include:
- Activation of Adenylyl Cyclase: This leads to the production of cyclic AMP (cAMP), a secondary messenger that further propagates the signal. - Activation of Phospholipase C: This results in the generation of inositol triphosphate (IP3) and diacylglycerol (DAG), which mobilize intracellular calcium and activate protein kinase C (PKC), respectively. - Regulation of Ion Channels: GPCRs can also modulate the activity of ion channels, affecting the flow of ions such as Ca²⁺, Na⁺, and K⁺ across the cell membrane.
