What Are the Implications of GPCR Catalysis in Drug Development?
GPCRs are a major target for drug development due to their pivotal role in various physiological processes. Understanding the catalytic mechanisms of GPCRs can aid in the design of drugs that specifically modulate these receptors' activity. For instance, agonists can mimic natural ligands to activate GPCRs, while antagonists can block ligand binding, thus modulating the receptor's catalytic activity. This has significant implications for treating conditions such as cardiovascular diseases, neurological disorders, and cancers.
