How Are GPCRs Studied in the Context of Catalysis?
The study of GPCRs in catalysis involves a combination of biochemical, biophysical, and computational techniques. Crystallography and cryo-electron microscopy have provided detailed structural insights into GPCRs, revealing how ligand binding induces conformational changes. Additionally, techniques such as fluorescence resonance energy transfer (FRET) and bioluminescence resonance energy transfer (BRET) are used to study the dynamics of GPCR activation and G protein interaction.
