What is the Mechanism of Action of Arginine Deiminase (ADI)?
ADI catalyzes the conversion of arginine into citrulline and ammonia. This reaction essentially removes arginine from the tumor microenvironment. Since arginine is crucial for the survival of these cancer cells, its depletion leads to cell cycle arrest and apoptosis. Additionally, the conversion of arginine to citrulline allows for potential recycling back into the urea cycle, which can be beneficial in reducing systemic toxicity.
