What are the Applications of Arginine-Depleting Enzymes?
Arginine-depleting enzymes have been explored in various therapeutic strategies. For instance, ADI has been used in clinical trials to treat certain types of cancers, such as hepatocellular carcinoma and melanoma. By catalyzing the hydrolysis of arginine into citrulline and ammonia, ADI reduces the availability of arginine, thereby limiting the growth of arginine-dependent tumors.
