Are There Any Challenges Associated with Arginine Deprivation Therapy?
Despite its promise, arginine deprivation therapy faces several challenges. One major concern is the potential for toxicity and immunogenicity of the enzyme-based treatments. Additionally, some cancer cells may develop resistance to arginine deprivation by upregulating alternative pathways or acquiring the ability to synthesize arginine independently. Overcoming these challenges requires a deeper understanding of the tumor biology and the development of more sophisticated delivery systems.
