What is the Catalytic Mechanism of Myeloperoxidase?
The catalytic mechanism of MPO involves several steps:
Formation of Compound I: MPO reacts with H2O2 to form Compound I, a highly reactive intermediate. Reduction of Compound I: Compound I is then reduced by Cl- to form Compound II, generating HOCl in the process. Regeneration of MPO: Compound II is subsequently reduced back to its native form, completing the catalytic cycle.
