MPO activity is regulated through multiple mechanisms, including:
Gene Expression: The expression of the MPO gene can be upregulated in response to infections and inflammatory signals. Post-translational Modifications: MPO can undergo post-translational modifications that affect its activity and stability. Inhibitors: Various endogenous and exogenous inhibitors can modulate MPO activity. For example, certain antioxidants can scavenge the reactive species produced by MPO, thereby reducing its activity.
