What are the Challenges in Studying Myeloperoxidase Catalysis?
Studying MPO catalysis presents several challenges:
Complexity of Reaction Mechanisms: The reaction mechanisms of MPO are complex and involve multiple intermediates and pathways. Detection of Reactive Species: The reactive species produced by MPO, such as HOCl, are short-lived and difficult to detect and quantify. In Vivo vs. In Vitro Conditions: The conditions under which MPO operates in vivo can be difficult to replicate accurately in vitro, complicating the study of its catalytic properties.
