What is the Biological Significance of Histone Demethylases?
The biological significance of histone demethylases extends across various cellular processes. They are involved in the regulation of [gene expression](href), maintenance of [genome integrity](href), and modulation of [cell cycle](href). Aberrant activity of histone demethylases has been linked with numerous diseases, including cancers, neurodegenerative disorders, and developmental abnormalities. For instance, overexpression of [KDM4A](href), a JmjC family member, has been associated with several types of cancer.
