What Are the Challenges in Studying Histone Demethylases?
Studying histone demethylases presents several challenges. One significant challenge is the dynamic and context-dependent nature of their activity, which can vary between different cell types and physiological conditions. Additionally, the redundancy and overlap in the functions of various demethylases complicate the task of delineating their specific roles. Advanced techniques in [genomics](href), [proteomics](href), and [bioinformatics](href) are being employed to overcome these challenges and gain a deeper understanding of these critical enzymes.
