Histone demethylases are crucial for the dynamic regulation of the epigenome. By removing methyl groups from [lysine](href) or [arginine](href) residues on histones, these enzymes can either repress or activate gene expression. Their activity is tightly regulated and often context-dependent, involving a complex interplay with other histone modifications and epigenetic markers. This dynamic regulation is essential for processes such as cell differentiation, development, and response to environmental stimuli.
