The HECT domain, short for "Homologous to the E6-AP Carboxyl Terminus," is a protein domain that plays a crucial role in the ubiquitination process. This domain is found in a specific class of E3 ubiquitin ligases known as HECT E3 ligases. Ubiquitination is a post-translational modification where ubiquitin, a small regulatory protein, is attached to a substrate protein, marking it for various cellular processes, including degradation, signal transduction, and endocytosis.
