Several factors can lead to site blocking: - Adsorption of byproducts: Byproducts of reactions may strongly adsorb onto active sites. - Coking: Deposition of carbonaceous materials, known as coke, on the catalyst surface. - Contaminants: Impurities in the feedstock or reaction environment. - Sintering: Loss of active surface area due to the agglomeration of catalytic particles at high temperatures.