What are the substrates and products of PARP-catalyzed reactions?
The primary substrate for PARP is NAD+ (Nicotinamide Adenine Dinucleotide). During the catalytic process, PARP transfers ADP-ribose units from NAD+ to specific amino acid residues on target proteins, primarily glutamate, aspartate, and lysine. The products of this catalysis are poly ADP-ribosylated proteins and nicotinamide.
