What are the challenges in targeting PARP catalysis?
One of the major challenges in targeting PARP catalysis is achieving specificity. PARP family consists of 17 different proteins, each with distinct and overlapping functions. Designing inhibitors that selectively target a specific PARP enzyme without affecting others is complex. Additionally, understanding the off-target effects and long-term consequences of PARP inhibition is crucial for developing safe and effective therapies.
