Several strategies can be employed in ligand design:
Electronic Tuning: Modifying the electronic properties of the ligand to influence the metal center's reactivity. Steric Control: Designing ligands with specific shapes and sizes to control the spatial arrangement of substrates. Functional Group Incorporation: Adding functional groups to the ligand to introduce additional reactivity or binding sites. Computational Design: Using computational tools to predict and optimize ligand structures. High-throughput Screening: Rapidly testing a large number of ligands to identify the most effective ones.
