What are the Clinical Implications of LPL Dysfunction?
Deficiencies or dysfunctions in LPL can lead to several metabolic disorders. For instance:
1. Hyperlipidemia: Elevated levels of circulating triglycerides due to insufficient hydrolysis by LPL. 2. Atherosclerosis: Excess triglycerides and cholesterol can deposit in arterial walls, leading to plaque formation. 3. Insulin Resistance: Impaired LPL activity can lead to altered lipid metabolism, contributing to insulin resistance and type 2 diabetes.
