Several factors can influence the activity of LPL, including:
1. Cofactors: Apolipoprotein C-II acts as a cofactor and is required for LPL activation. 2. Inhibitors: Angiopoietin-like proteins, particularly ANGPTL4, inhibit LPL activity. 3. pH and Temperature: LPL has an optimal pH and temperature range, typically around a neutral pH and physiological temperature. 4. Post-translational Modifications: Glycosylation and phosphorylation can affect LPL's stability and activity.
