Regulation of transcriptional catalysis occurs through multiple mechanisms: - Epigenetic Modifications: Chemical modifications such as [methylation](#) and acetylation of DNA and histone proteins can affect chromatin structure, making it more or less accessible for transcription. - Feedback Loops: Gene products can feedback to influence their own expression levels. - Signal Transduction Pathways: External signals like hormones or nutrients can activate transcription factors through various signaling pathways, thereby influencing transcription.