Why is E3 Ubiquitin Ligase Important in Catalysis?
E3 ubiquitin ligases are vital for maintaining cellular homeostasis. They regulate the degradation of misfolded or damaged proteins, thus preventing the accumulation of toxic protein aggregates. This catalytic activity is also crucial in modulating the levels of key regulatory proteins involved in cell cycle control, apoptosis, and signal transduction pathways, thereby influencing various physiological and pathological processes.
