Thioredoxin reductase (TrxR) is a crucial enzyme that plays a significant role in cellular redox homeostasis. It catalyzes the reduction of thioredoxin (Trx), a small protein that acts as an antioxidant by facilitating the reduction of other proteins. TrxR itself is a member of the family of pyridine nucleotide-disulfide oxidoreductases, which typically use NADPH as a cofactor.
