What is the Mechanism of Enzymatic Catalysis in Histone Modification?
Enzymatic catalysis in histone modification involves the enzyme binding to both the histone substrate and the donor molecule (like acetyl-CoA for acetylation or S-adenosylmethionine for methylation). The enzyme then facilitates the transfer of the functional group from the donor molecule to the histone, often through a series of intermediate steps that lower the activation energy of the reaction.
