What Challenges Exist in Targeting Tumor Metabolism?
One major challenge in targeting tumor metabolism is the metabolic flexibility of cancer cells. Tumors can adapt to metabolic stress by activating alternative pathways or by utilizing different substrates. Additionally, the heterogeneity of tumors means that metabolic dependencies can vary between different types of cancer and even between different cells within the same tumor. This makes it difficult to develop universal metabolic inhibitors that are effective across all cancers.
