The structural study of Frh has revealed that it consists of multiple subunits, often organized into a complex quaternary structure. Key features include the presence of iron-sulfur clusters and a nickel-containing active site. These [metal clusters](#) are crucial for the enzyme's activity, facilitating the transfer of electrons during the catalytic cycle. Structural insights into Frh have been obtained through techniques such as X-ray crystallography and cryo-electron microscopy.
