What are the Structural Components of the Proteasome?
The proteasome is composed of a 20S core particle and one or two 19S regulatory particles. The 20S core is a barrel-shaped structure made of four stacked rings, each consisting of seven subunits. The 19S regulatory particles are responsible for recognizing ubiquitinated proteins, unfolding them, and translocating them into the 20S core. The regulatory particles also play a role in deubiquitination, removing ubiquitin chains before degradation.
