Why is Proteasome Activity Important for Cellular Function?
Proteasome-mediated proteolysis is vital for numerous cellular functions and processes. It regulates the concentration of key proteins involved in the cell cycle, thus controlling cell division and proliferation. It also removes misfolded or damaged proteins, preventing the accumulation of toxic aggregates that can lead to diseases such as Alzheimer's and Parkinson's. Additionally, proteasome activity modulates the immune response by generating peptides for antigen presentation.
