What are the Research Directions in Proteasome Catalysis?
Research in proteasome catalysis is focused on understanding the detailed mechanisms of substrate recognition, unfolding, and degradation. Structural studies using techniques like cryo-electron microscopy are providing insights into the dynamic processes within the proteasome. Additionally, there is interest in developing selective proteasome inhibitors and activators as therapeutic agents. Understanding how proteasomes interact with different substrates and regulatory proteins can lead to novel strategies for treating diseases associated with proteasome dysfunction.
