What are the Recent Advances in IDO Catalysis Research?
Recent advances in IDO catalysis research have focused on elucidating the detailed reaction mechanism and identifying novel inhibitors. High-resolution structural studies have provided insights into the enzyme's active site and substrate binding. Moreover, computational modeling and quantum mechanics/molecular mechanics (QM/MM) simulations have been employed to understand the electronic and structural properties of the enzyme during catalysis. These studies are paving the way for the rational design of more potent and selective IDO inhibitors.
