Several factors contribute to uneven distribution:
1. Synthesis Methods: Poor control over the synthesis of catalysts can lead to non-uniform particle sizes and shapes. 2. Support Material: In heterogeneous catalysis, the surface properties of the support material can influence how well the catalyst is dispersed. 3. Reactor Design: The design and operation of the reactor can lead to uneven flow patterns, affecting the distribution of the catalyst. 4. Deactivation: Over time, catalysts can deactivate unevenly due to fouling, poisoning, or thermal degradation.