What are the Mechanistic Steps of the Mizoroki-Heck Reaction?
The Mizoroki-Heck Reaction involves several key mechanistic steps: 1. Oxidative Addition: The palladium catalyst undergoes oxidative addition with the aryl halide, forming a palladium-aryl complex. 2. Coordination and Insertion: The alkene coordinates to the palladium center, followed by the insertion of the alkene into the palladium-aryl bond. 3. β-Hydride Elimination: This step leads to the formation of the product with the new C-C bond and regenerates the palladium catalyst.
