What are the Limitations and Challenges of the Mizoroki-Heck Reaction?
Despite its numerous advantages, the Mizoroki-Heck Reaction has some limitations. These include: - Functional Group Compatibility: Certain functional groups may not be compatible with the reaction conditions, limiting the substrate scope. - Regioselectivity: Achieving high regioselectivity can be challenging, especially with substituted alkenes. - Catalyst Deactivation: The palladium catalyst can undergo deactivation, reducing the reaction's efficiency over time.
