What are the Mechanistic Insights of GroES-GroEL Complex?
The GroES-GroEL complex functions through a mechanism often referred to as the "Anfinsen cage" model. In this model, the GroEL subunits form a double-ring structure with a central cavity, while GroES caps this structure. The process begins with an unfolded protein entering the GroEL cavity, followed by GroES binding to GroEL, which encloses the protein inside. This enclosed environment enables the protein to fold without forming incorrect interactions. The process is ATP-dependent, with ATP binding and hydrolysis driving conformational changes that facilitate protein folding and release.
