What are the Mechanisms of Bafilomycin's Inhibitory Action?
The primary mechanism of Bafilomycin's action is its binding to the c-subunit of the V-ATPase complex. This binding prevents the rotation of the c-ring, which is essential for ATP hydrolysis and subsequent proton translocation. As a result, the enzyme's ability to catalyze the conversion of ATP to ADP and inorganic phosphate is inhibited.
