Several viral proteins are identified as key catalytic targets:
RNA-dependent RNA Polymerase (RdRp): This enzyme catalyzes the synthesis of viral RNA from an RNA template. Inhibitors like Remdesivir target RdRp to disrupt viral replication. Main Protease (Mpro): This enzyme processes viral polyproteins into functional proteins necessary for replication. Inhibitors like PF-07321332 target Mpro to block this processing. Papain-like Protease (PLpro): This enzyme also processes viral polyproteins and has roles in evading the host immune response. Inhibitors targeting PLpro can hinder viral replication and modulate immune responses.
