What Are the Design Principles for Peptidyl Mimetics in Catalysis?
The design of peptidyl mimetics for catalytic purposes involves several key principles:
Structural Mimicry: The mimetic must closely resemble the active site of the enzyme it is intended to replicate. Stability: The mimetic should be chemically stable under the conditions required for the catalytic reaction. Functional Group Placement: Functional groups must be accurately positioned to facilitate the desired chemical transformation. Modularity: The design should allow for modifications to tailor the catalyst for specific reactions.
