What Are the Challenges in Developing Peptidyl Mimetics for Catalysis?
Despite their potential, the development of peptidyl mimetics for catalytic applications faces several challenges:
Complexity of Design: Designing a mimetic that accurately replicates the active site of an enzyme can be highly complex and requires a deep understanding of both peptide chemistry and enzymology. Cost: The synthesis of peptidyl mimetics can be expensive, which may limit their practical applications. Optimization: Each new mimetic may require extensive optimization to achieve the desired catalytic activity and selectivity.
