What are the Clinical Implications of NOS Dysfunction?
Dysregulation of NOS activity is implicated in various diseases. Overproduction of NO by iNOS is associated with inflammatory conditions and septic shock. Conversely, reduced NO production by eNOS is linked to cardiovascular diseases such as hypertension and atherosclerosis. Understanding the catalytic mechanisms and regulation of NOS can thus aid in the development of therapeutic strategies for these conditions.
