What are the Clinical Implications of Aldolase Deficiency?
A deficiency in aldolase, particularly aldolase B, can lead to serious metabolic disorders such as Hereditary Fructose Intolerance (HFI). Individuals with HFI lack the ability to properly metabolize fructose, leading to severe symptoms such as hypoglycemia, jaundice, and potential liver failure upon ingestion of fructose-containing foods.
